7MME
Crystal structure of HCV NS3/4A D168A protease in complex with JZ01-15
Summary for 7MME
Entry DOI | 10.2210/pdb7mme/pdb |
Descriptor | NS3/4A protease, tert-butyl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate, ZINC ION, ... (7 entities in total) |
Functional Keywords | ns3/4a protease, hepatitis c virus, drug resistance, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex, viral protein, hydrolase/inhibitor |
Biological source | Hepacivirus C |
Total number of polymer chains | 1 |
Total formula weight | 22662.96 |
Authors | Zephyr, J.,Schiffer, C.A. (deposition date: 2021-04-29, release date: 2022-08-31, Last modification date: 2023-10-18) |
Primary citation | Zephyr, J.,Nageswara Rao, D. Deciphering the Molecular Mechanism and Role of Fluorination in HCV Protease Inhibitor Potency and Drug Resistance To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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