7MMD

Crystal structure of HCV NS3/4A D168A protease in complex with JZ01-19

7MMD の概要

• エントリーDOI: 10.2210/pdb7mmd/pdb
• 分子名称: NS3/4A protease, 1,2-ETHANEDIOL, ZINC ION, ... (6 entities in total)
• 機能のキーワード: ns3/4a protease, hepatitis c virus, drug resistance, protease inhibitor, hydrolase-inhibitor complex, viral protein, hydrolase/inhibitor
• 由来する生物種: Hepacivirus C
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22456.79

構造登録者

Zephyr, J.,Schiffer, C.A. (登録日: 2021-04-29, 公開日: 2022-08-31, 最終更新日: 2023-10-18)

• 主引用文献: Zephyr, J.,Nageswara Rao, D.,Vo, S.V.,Henes, M.,Kosovrasti, K.,Matthew, A.N.,Hedger, A.K.,Timm, J.,Chan, E.T.,Ali, A.,Kurt Yilmaz, N.,Schiffer, C.A.; Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.; J.Mol.Biol., 434:167503-167503, 2022; PubMed: 35183560; DOI: 10.1016/j.jmb.2022.167503

実験手法

X-RAY DIFFRACTION (1.89 Å)