7MM4

Crystal structure of HCV NS3/4A protease in complex with NR01-115

Summary for 7MM4

Entry DOI	10.2210/pdb7mm4/pdb
Descriptor	NS3 protease, ZINC ION, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	ns3/4a protease, hepatitis c virus, drug resistance, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex, viral protein, hydrolase/inhibitor
Biological source	Hepacivirus C
Total number of polymer chains	1
Total formula weight	22873.21
Authors	Zephyr, J.,Schiffer, C.A. (deposition date: 2021-04-29, release date: 2022-03-16, Last modification date: 2023-10-18)
Primary citation	Zephyr, J.,Nageswara Rao, D.,Vo, S.V.,Henes, M.,Kosovrasti, K.,Matthew, A.N.,Hedger, A.K.,Timm, J.,Chan, E.T.,Ali, A.,Kurt Yilmaz, N.,Schiffer, C.A. Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance. J.Mol.Biol., 434:167503-167503, 2022 Cited by PubMed: 35183560 DOI: 10.1016/j.jmb.2022.167503 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation