7MLP

Crystal structure of ricin A chain in complex with 5-(2,6-dimethylphenyl)thiophene-2-carboxylic acid

7MLP の概要

• エントリーDOI: 10.2210/pdb7mlp/pdb
• 分子名称: Ricin, 5-(2,6-dimethylphenyl)thiophene-2-carboxylic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: ricin chain-a, rta, hydrolase, toxin, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Ricinus communis (Castor bean)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30803.48

構造登録者

Harijan, R.K.,Li, X.P.,Cao, B.,Augeri, D.,Bonanno, J.B.,Almo, S.C.,Tumer, N.E.,Schramm, V.L. (登録日: 2021-04-28, 公開日: 2022-02-09, 最終更新日: 2023-10-18)

• 主引用文献: Li, X.P.,Harijan, R.K.,Cao, B.,Kahn, J.N.,Pierce, M.,Tsymbal, A.M.,Roberge, J.Y.,Augeri, D.,Tumer, N.E.; Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design.; J.Med.Chem., 64:15334-15348, 2021; PubMed: 34648707; DOI: 10.1021/acs.jmedchem.1c01370

実験手法

X-RAY DIFFRACTION (1.78 Å)