7MLH

Crystal structure of human IgE (2F10) in complex with Der p 2.0103

Summary for 7MLH

Entry DOI	10.2210/pdb7mlh/pdb
Descriptor	IgE Light Chain, Der p 2 variant 3, IgE Heavy chain, ... (6 entities in total)
Functional Keywords	allergy, ige, house dust mites, antibody, allergen, allergen-immune system complex, allergen/immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	124129.10
Authors	Khatri, K.,Kapingidza, A.B.,Richardson, C.M.,Vailes, L.D.,Wunschmann, S.,Dolamore, C.,Chapman, M.D.,Smith, S.A.,Pomes, A.,Chruszcz, M. (deposition date: 2021-04-28, release date: 2022-05-04, Last modification date: 2023-10-18)
Primary citation	Khatri, K.,Richardson, C.M.,Glesner, J.,Kapingidza, A.B.,Mueller, G.A.,Zhang, J.,Dolamore, C.,Vailes, L.D.,Wunschmann, S.,Peebles Jr., R.S.,Chapman, M.D.,Smith, S.A.,Chruszcz, M.,Pomes, A. Human IgE monoclonal antibody recognition of mite allergen Der p 2 defines structural basis of an epitope for IgE cross-linking and anaphylaxis in vivo. Pnas Nexus, 1:pgac054-pgac054, 2022 Cited by PubMed: 35799831 DOI: 10.1093/pnasnexus/pgac054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation