7MKY

SARS-CoV-2 frameshifting pseudoknot RNA

Summary for 7MKY

Entry DOI	10.2210/pdb7mky/pdb
Descriptor	RNA (66-MER), COBALT HEXAMMINE(III), POTASSIUM ION, ... (7 entities in total)
Functional Keywords	pseudoknot, tetraloop, triple, sars, virus, covid, coronavirus, severe acute respiratory syndrome, frameshift, rna
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	1
Total formula weight	21954.86
Authors	Jones, C.P.,Ferre-D'Amare, A.R. (deposition date: 2021-04-27, release date: 2021-05-26, Last modification date: 2023-10-18)
Primary citation	Jones, C.P.,Ferre-D'Amare, A.R. Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot. Rna, 28:239-249, 2022 Cited by PubMed Abstract: SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 Å-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the ribosome and exhibits base-triple-adjacent pockets that could be targeted by future small-molecule therapeutics. PubMed: 34845084 DOI: 10.1261/rna.078825.121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.31 Å)

Structure validation