7MKL

SARS-CoV-2 Spike in complex with neutralizing Fab SARS2-38 (three down conformation)

7MKL の概要

• エントリーDOI: 10.2210/pdb7mkl/pdb
• EMDBエントリー: 23898 23899
• 分子名称: Spike glycoprotein, SARS2-38 Fv heavy chain, SARS2-38 Fv light chain, ... (5 entities in total)
• 機能のキーワード: glycoprotein, antibody, viral protein-immune system complex, structural genomics, center for structural genomics of infectious diseases, csgid, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 410034.17

構造登録者

Adams, L.J.,Fremont, D.H.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2021-04-24, 公開日: 2021-05-12, 最終更新日: 2021-12-01)

• 主引用文献: VanBlargan, L.A.,Adams, L.J.,Liu, Z.,Chen, R.E.,Gilchuk, P.,Raju, S.,Smith, B.K.,Zhao, H.,Case, J.B.,Winkler, E.S.,Whitener, B.M.,Droit, L.,Aziati, I.D.,Bricker, T.L.,Joshi, A.,Shi, P.Y.,Creanga, A.,Pegu, A.,Handley, S.A.,Wang, D.,Boon, A.C.M.,Crowe Jr., J.E.,Whelan, S.P.J.,Fremont, D.H.,Diamond, M.S.; A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope.; Immunity, 54:2399-2416.e6, 2021; PubMed: 34481543; DOI: 10.1016/j.immuni.2021.08.016

実験手法

ELECTRON MICROSCOPY (3.2 Å)