7MJA

HLA-A*24:02 bound to Neuroblastoma derived PHOX2B peptide

7MJA の概要

• エントリーDOI: 10.2210/pdb7mja/pdb
• 分子名称: HLA class I histocompatibility antigen, Beta-2-microglobulin, Paired mesoderm homeobox protein 2B peptide, ... (5 entities in total)
• 機能のキーワード: neuroblastoma tumor antigen, phox2b, igfbpl1, human major histocompatibility complex class i, mhc-i, complex, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 45578.59

構造登録者

Toor, J.S.,Tripathi, S.M.,Truong, H.V.,Yarmarkovich, M.,Maris, J.M.,Sgourakis, N.G. (登録日: 2021-04-19, 公開日: 2021-08-18, 最終更新日: 2023-10-18)

• 主引用文献: Yarmarkovich, M.,Marshall, Q.F.,Warrington, J.M.,Premaratne, R.,Farrel, A.,Groff, D.,Li, W.,di Marco, M.,Runbeck, E.,Truong, H.,Toor, J.S.,Tripathi, S.,Nguyen, S.,Shen, H.,Noel, T.,Church, N.L.,Weiner, A.,Kendsersky, N.,Martinez, D.,Weisberg, R.,Christie, M.,Eisenlohr, L.,Bosse, K.R.,Dimitrov, D.S.,Stevanovic, S.,Sgourakis, N.G.,Kiefel, B.R.,Maris, J.M.; Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.; Nature, 599:477-484, 2021; PubMed: 34732890; DOI: 10.1038/s41586-021-04061-6

実験手法

X-RAY DIFFRACTION (1.69 Å)