7MGV

Chryseobacterium gregarium RiPP-associated ATP-grasp ligase in complex with ADP, and a leader and core peptide

7MGV の概要

• エントリーDOI: 10.2210/pdb7mgv/pdb
• 分子名称: CdnC, CdnA3 Leader peptide, CdnA3 Core peptide, ... (6 entities in total)
• 機能のキーワード: ribosomally synthesized, post-translationally modified peptide, natural products atp-grasp ligase, precursor peptide, graspetide omega-ester macrocycles macrolactone, ligase
• 由来する生物種: Chryseobacterium gregarium DSM 19109; 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 88320.25

構造登録者

Bewley, C.A.,Zhao, G.,Kosek, D.,Dyda, F. (登録日: 2021-04-13, 公開日: 2021-06-23, 最終更新日: 2023-10-18)

• 主引用文献: Zhao, G.,Kosek, D.,Liu, H.B.,Ohlemacher, S.I.,Blackburne, B.,Nikolskaya, A.,Makarova, K.S.,Sun, J.,Barry Iii, C.E.,Koonin, E.V.,Dyda, F.,Bewley, C.A.; Structural Basis for a Dual Function ATP Grasp Ligase That Installs Single and Bicyclic omega-Ester Macrocycles in a New Multicore RiPP Natural Product.; J.Am.Chem.Soc., 143:8056-8068, 2021; PubMed: 34028251; DOI: 10.1021/jacs.1c02316

実験手法

X-RAY DIFFRACTION (2.44 Å)