7MFH

Crystal structure of BIO-32546 bound mouse Autotaxin

7MFH の概要

• エントリーDOI: 10.2210/pdb7mfh/pdb
• 分子名称: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: hydrolase inhibitor, autotaxin, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 99445.25

構造登録者

Chodaparambil, J.V. (登録日: 2021-04-09, 公開日: 2022-04-13, 最終更新日: 2023-10-18)

• 主引用文献: Ma, B.,Zhang, L.,Sun, L.,Xin, Z.,Kumaravel, G.,Marcotte, D.,Chodaparambil, J.V.,Wang, Q.,Wehr, A.,Jing, J.,Hong, V.S.,Wang, T.,Huang, C.,Shao, Z.,Mi, S.; Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546.; Acs Med.Chem.Lett., 12:1124-1129, 2021; PubMed: 34267882; DOI: 10.1021/acsmedchemlett.1c00211

実験手法

X-RAY DIFFRACTION (2.3 Å)