7MEE

CDD-1 beta-lactamase in imidazole/MPD 6 minute avibactam complex

Summary for 7MEE

Entry DOI	10.2210/pdb7mee/pdb
Related	7LNO 7LNQ 7LNR
Descriptor	Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, CARBON DIOXIDE, ... (6 entities in total)
Functional Keywords	gram-positive, beta-lactamase, antibiotic resistance, inhibitor, avibactam, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Clostridioides difficile (Peptoclostridium difficile)
Total number of polymer chains	1
Total formula weight	29291.87
Authors	Smith, C.A.,Vakulenko, S.B. (deposition date: 2021-04-06, release date: 2022-02-16)
Primary citation	Stewart, N.K.,Toth, M.,Stasyuk, A.,Vakulenko, S.B.,Smith, C.A. In Crystallo Time-Resolved Interaction of the Clostridioides difficile CDD-1 enzyme with Avibactam Provides New Insights into the Catalytic Mechanism of Class D beta-lactamases. Acs Infect Dis., 7:1765-1776, 2021 Cited by PubMed: 33908775 DOI: 10.1021/acsinfecdis.1c00094 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation