7MBY

Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex

7MBY の概要

• エントリーDOI: 10.2210/pdb7mby/pdb
• EMDBエントリー: 23750
• 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Cholecystokinin-8, ... (6 entities in total)
• 機能のキーワード: gpcr, membrane protein, membrane protein-signaling protein complex, membrane protein/signaling protein
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 123806.90

構造登録者

Mobbs, J.I.,Belousoff, M.J.,Danev, R.,Thal, D.M.,Sexton, P.M. (登録日: 2021-04-01, 公開日: 2021-05-26, 最終更新日: 2021-07-14)

• 主引用文献: Mobbs, J.I.,Belousoff, M.J.,Harikumar, K.G.,Piper, S.J.,Xu, X.,Furness, S.G.B.,Venugopal, H.,Christopoulos, A.,Danev, R.,Wootten, D.,Thal, D.M.,Miller, L.J.,Sexton, P.M.; Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.; Plos Biol., 19:e3001295-e3001295, 2021; PubMed: 34086670; DOI: 10.1371/journal.pbio.3001295

実験手法

ELECTRON MICROSCOPY (2.44 Å)