7MBJ

Crystal structure of cGMP dependent protein kinase I alpha (PKG I alpha)CNB-A domain with R177Q mutation

7MBJ の概要

• エントリーDOI: 10.2210/pdb7mbj/pdb
• 分子名称: cGMP-dependent protein kinase 1 (2 entities in total)
• 機能のキーワード: cgmp dependent protein kinase i alpha, second messenger, thoracic aortic aneurysms and aortic dissections causing mutation, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30551.66

構造登録者

Kim, J.J.,Casteel, D.E.,Kim, C. (登録日: 2021-03-31, 公開日: 2022-05-11, 最終更新日: 2023-10-18)

• 主引用文献: Sharma, R.,Kim, J.J.,Qin, L.,Henning, P.,Akimoto, M.,VanSchouwen, B.,Kaur, G.,Sankaran, B.,MacKenzie, K.R.,Melacini, G.,Casteel, D.E.,Herberg, F.W.,Kim, C.W.; An auto-inhibited state of protein kinase G and implications for selective activation.; Elife, 11:-, 2022; PubMed: 35929723; DOI: 10.7554/eLife.79530

実験手法

X-RAY DIFFRACTION (1.26 Å)