7MB6

SARS-CoV-2 Main Protease (Mpro) C145A in Complex with Cleavage Site Nsp6/7 (P6-P1)

7MB6 の概要

• エントリーDOI: 10.2210/pdb7mb6/pdb
• 分子名称: 3C-like proteinase, LYS-VAL-ALA-THR-VAL-GLN (3 entities in total)
• 機能のキーワード: sars-cov-2, covid-19, covid19 protease, protease inhibitor, complex, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 68232.73

構造登録者

Lockbaum, G.J.,Schiffer, C.A. (登録日: 2021-03-31, 公開日: 2022-06-22, 最終更新日: 2023-10-18)

• 主引用文献: Shaqra, A.M.,Zvornicanin, S.N.,Huang, Q.Y.J.,Lockbaum, G.J.,Knapp, M.,Tandeske, L.,Bakan, D.T.,Flynn, J.,Bolon, D.N.A.,Moquin, S.,Dovala, D.,Kurt Yilmaz, N.,Schiffer, C.A.; Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.; Nat Commun, 13:3556-3556, 2022; PubMed: 35729165; DOI: 10.1038/s41467-022-31210-w

実験手法

X-RAY DIFFRACTION (2.21 Å)