7M7A

Legionella pneumophila MavQ lipid kinase

7M7A の概要

• エントリーDOI: 10.2210/pdb7m7a/pdb
• 分子名称: Phosphoinositide 3-kinase MavQ, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION (3 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: Legionella pneumophila subsp. pneumophila
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 275723.34

構造登録者

Tomchick, D.R.,Tagliabracci, V.S.,Hsieh, T.S.,Lopez, V.A. (登録日: 2021-03-27, 公開日: 2021-04-28, 最終更新日: 2024-05-22)

主引用文献

Hsieh, T.S.,Lopez, V.A.,Black, M.H.,Osinski, A.,Pawlowski, K.,Tomchick, D.R.,Liou, J.,Tagliabracci, V.S.
Dynamic remodeling of host membranes by self-organizing bacterial effectors.
Science, 372:935-941, 2021

PubMed Abstract: During infection, intracellular bacterial pathogens translocate a variety of effectors into host cells that modify host membrane trafficking for their benefit. We found a self-organizing system consisting of a bacterial phosphoinositide kinase and its opposing phosphatase that formed spatiotemporal patterns, including traveling waves, to remodel host cellular membranes. The effector MavQ, a phosphatidylinositol (PI) 3-kinase, was targeted to the endoplasmic reticulum (ER). MavQ and the PI 3-phosphatase SidP, even in the absence of other bacterial components, drove rapid PI 3-phosphate turnover on the ER and spontaneously formed traveling waves that spread along ER subdomains inducing vesicle and tubule budding. Thus, bacteria can exploit a self-organizing membrane-targeting mechanism to hijack host cellular structures for survival.

PubMed: 33927055
DOI: 10.1126/science.aay8118

実験手法

X-RAY DIFFRACTION (3.2 Å)