7M6B

The Crystal Structure of Mcbe1

Summary for 7M6B

• Entry DOI: 10.2210/pdb7m6b/pdb
• Descriptor: Site-specific DNA-methyltransferase (adenine-specific), S-ADENOSYLMETHIONINE, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
• Functional Keywords: methyl transferase, transferase
• Biological source: Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
• Total number of polymer chains: 2
• Total formula weight: 68968.53

Authors

Alahuhta, P.M.,Lunin, V.V. (deposition date: 2021-03-25, release date: 2021-04-14, Last modification date: 2023-10-18)

Primary citation

Alexander, L.T.,Lepore, R.,Kryshtafovych, A.,Adamopoulos, A.,Alahuhta, M.,Arvin, A.M.,Bomble, Y.J.,Bottcher, B.,Breyton, C.,Chiarini, V.,Chinnam, N.B.,Chiu, W.,Fidelis, K.,Grinter, R.,Gupta, G.D.,Hartmann, M.D.,Hayes, C.S.,Heidebrecht, T.,Ilari, A.,Joachimiak, A.,Kim, Y.,Linares, R.,Lovering, A.L.,Lunin, V.V.,Lupas, A.N.,Makbul, C.,Michalska, K.,Moult, J.,Mukherjee, P.K.,Nutt, W.S.,Oliver, S.L.,Perrakis, A.,Stols, L.,Tainer, J.A.,Topf, M.,Tsutakawa, S.E.,Valdivia-Delgado, M.,Schwede, T.
Target highlights in CASP14: Analysis of models by structure providers.
Proteins, 89:1647-1672, 2021

PubMed Abstract: The biological and functional significance of selected Critical Assessment of Techniques for Protein Structure Prediction 14 (CASP14) targets are described by the authors of the structures. The authors highlight the most relevant features of the target proteins and discuss how well these features were reproduced in the respective submitted predictions. The overall ability to predict three-dimensional structures of proteins has improved remarkably in CASP14, and many difficult targets were modeled with impressive accuracy. For the first time in the history of CASP, the experimentalists not only highlighted that computational models can accurately reproduce the most critical structural features observed in their targets, but also envisaged that models could serve as a guidance for further studies of biologically-relevant properties of proteins.

PubMed: 34561912
DOI: 10.1002/prot.26247

Experimental method

X-RAY DIFFRACTION (1.9 Å)