7LYJ
SARS-CoV-2 frameshifting pseudoknot RNA
Summary for 7LYJ
| Entry DOI | 10.2210/pdb7lyj/pdb |
| Descriptor | RNA (66-MER), IRIDIUM HEXAMMINE ION, MAGNESIUM ION, ... (5 entities in total) |
| Functional Keywords | pseudoknot, tetraloop, triple, sars, virus, covid, coronavirus, severe acute respiratory syndrome, frameshift, rna |
| Biological source | Severe acute respiratory syndrome coronavirus 2 |
| Total number of polymer chains | 1 |
| Total formula weight | 22245.33 |
| Authors | Jones, C.P.,Ferre-D'Amare, A.R. (deposition date: 2021-03-07, release date: 2021-05-26, Last modification date: 2024-05-22) |
| Primary citation | Jones, C.P.,Ferre-D'Amare, A.R. Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot. Rna, 28:239-249, 2022 Cited by PubMed Abstract: SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 Å-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the ribosome and exhibits base-triple-adjacent pockets that could be targeted by future small-molecule therapeutics. PubMed: 34845084DOI: 10.1261/rna.078825.121 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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