7LYJ

SARS-CoV-2 frameshifting pseudoknot RNA

7LYJ の概要

• エントリーDOI: 10.2210/pdb7lyj/pdb
• 分子名称: RNA (66-MER), IRIDIUM HEXAMMINE ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: pseudoknot, tetraloop, triple, sars, virus, covid, coronavirus, severe acute respiratory syndrome, frameshift, rna
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22245.33

構造登録者

Jones, C.P.,Ferre-D'Amare, A.R. (登録日: 2021-03-07, 公開日: 2021-05-26, 最終更新日: 2024-05-22)

主引用文献

Jones, C.P.,Ferre-D'Amare, A.R.
Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot.
Rna, 28:239-249, 2022

PubMed Abstract: SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 Å-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the ribosome and exhibits base-triple-adjacent pockets that could be targeted by future small-molecule therapeutics.

PubMed: 34845084
DOI: 10.1261/rna.078825.121

実験手法

X-RAY DIFFRACTION (2.11 Å)