7LXL

Crystal structure of human CYP3A4 bound to the testosterone dimer

Summary for 7LXL

Entry DOI	10.2210/pdb7lxl/pdb
Descriptor	Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, 17alpha-hydroxy-7alpha-[(2Z)-4-(17beta-hydroxy-3-oxo-8alpha-androst-4-en-7beta-yl)but-2-en-1-yl]-8alpha,10alpha,13alpha,14beta-androst-4-en-3-one (3 entities in total)
Functional Keywords	cyp3a4, ligand, testosterone dimer, complex, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	56872.02
Authors	Sevrioukova, I.F. (deposition date: 2021-03-04, release date: 2021-04-28, Last modification date: 2023-10-18)
Primary citation	Paquin, A.,Oufqir, Y.,Sevrioukova, I.F.,Reyes-Moreno, C.,Berube, G. Innovative C 2 -symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4. Eur.J.Med.Chem., 220:113496-113496, 2021 Cited by PubMed: 33933755 DOI: 10.1016/j.ejmech.2021.113496 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation