7LXL

Crystal structure of human CYP3A4 bound to the testosterone dimer

7LXL の概要

• エントリーDOI: 10.2210/pdb7lxl/pdb
• 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, 17alpha-hydroxy-7alpha-[(2Z)-4-(17beta-hydroxy-3-oxo-8alpha-androst-4-en-7beta-yl)but-2-en-1-yl]-8alpha,10alpha,13alpha,14beta-androst-4-en-3-one (3 entities in total)
• 機能のキーワード: cyp3a4, ligand, testosterone dimer, complex, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56872.02

構造登録者

Sevrioukova, I.F. (登録日: 2021-03-04, 公開日: 2021-04-28, 最終更新日: 2023-10-18)

• 主引用文献: Paquin, A.,Oufqir, Y.,Sevrioukova, I.F.,Reyes-Moreno, C.,Berube, G.; Innovative C 2 -symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4.; Eur.J.Med.Chem., 220:113496-113496, 2021; PubMed: 33933755; DOI: 10.1016/j.ejmech.2021.113496

実験手法

X-RAY DIFFRACTION (2.75 Å)