7LVM

CASP8 isoform B DED domain

Summary for 7LVM

• Entry DOI: 10.2210/pdb7lvm/pdb
• Descriptor: Caspase-8 (2 entities in total)
• Functional Keywords: casp8, gene id: 841, casp8b ded, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 22413.79

Authors

Weichert, K.,Lu, F.,Kodandapani, L.,Sauder, J.M. (deposition date: 2021-02-25, release date: 2022-03-02, Last modification date: 2024-04-03)

Primary citation

Ansalone, C.,Ainsworth, R.I.,Nygaard, G.,Ai, R.,Prideaux, E.B.,Hammaker, D.,Perumal, N.B.,Weichert, K.,Tung, F.,Kodandapani, L.,Sauder, J.M.,Mertsching, E.C.,Benschop, R.J.,Boyle, D.L.,Wang, W.,Firestein, G.S.
Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior.
ACR Open Rheumatol, 4:288-299, 2022

PubMed Abstract: Fibroblast-like synoviocytes (FLS) play a pivotal role in rheumatoid arthritis (RA) by contributing to synovial inflammation and progressive joint damage. An imprinted epigenetic state is associated with the FLS aggressive phenotype. We identified CASP8 (encoding for caspase-8) as a differentially marked gene and evaluated its pathogenic role in RA FLSs.

PubMed: 34963199
DOI: 10.1002/acr2.11384

Experimental method

X-RAY DIFFRACTION (1.47 Å)