7LV8

Structure of the Marseillevirus nucleosome

Summary for 7LV8

• Entry DOI: 10.2210/pdb7lv8/pdb
• EMDB information: 23529 23530
• Descriptor: Histone doublet Delta-Gamma (Delta), Histone doublet Delta-Gamma (Gamma), Histone doublet Beta-Alpha (Beta), ... (6 entities in total)
• Functional Keywords: structural protein/dna, structural protein, structural protein-dna complex
• Biological source: Marseillevirus marseillevirus (GBM); More
• Total number of polymer chains: 10
• Total formula weight: 176950.91

Authors

Valencia-Sanchez, M.I.,Abini-Agbomson, S.,Armache, K.-J. (deposition date: 2021-02-24, release date: 2021-05-05, Last modification date: 2024-10-09)

Primary citation

Valencia-Sanchez, M.I.,Abini-Agbomson, S.,Wang, M.,Lee, R.,Vasilyev, N.,Zhang, J.,De Ioannes, P.,La Scola, B.,Talbert, P.,Henikoff, S.,Nudler, E.,Erives, A.,Armache, K.J.
The structure of a virus-encoded nucleosome.
Nat.Struct.Mol.Biol., 28:413-417, 2021

PubMed Abstract: Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.

PubMed: 33927388
DOI: 10.1038/s41594-021-00585-7

Experimental method

ELECTRON MICROSCOPY (3.4 Å)