7LV8

Structure of the Marseillevirus nucleosome

7LV8 の概要

• エントリーDOI: 10.2210/pdb7lv8/pdb
• EMDBエントリー: 23529 23530
• 分子名称: Histone doublet Delta-Gamma (Delta), Histone doublet Delta-Gamma (Gamma), Histone doublet Beta-Alpha (Beta), ... (6 entities in total)
• 機能のキーワード: structural protein/dna, structural protein, structural protein-dna complex
• 由来する生物種: Marseillevirus marseillevirus (GBM); 詳細
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 176950.91

構造登録者

Valencia-Sanchez, M.I.,Abini-Agbomson, S.,Armache, K.-J. (登録日: 2021-02-24, 公開日: 2021-05-05, 最終更新日: 2024-10-09)

主引用文献

Valencia-Sanchez, M.I.,Abini-Agbomson, S.,Wang, M.,Lee, R.,Vasilyev, N.,Zhang, J.,De Ioannes, P.,La Scola, B.,Talbert, P.,Henikoff, S.,Nudler, E.,Erives, A.,Armache, K.J.
The structure of a virus-encoded nucleosome.
Nat.Struct.Mol.Biol., 28:413-417, 2021

PubMed Abstract: Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.

PubMed: 33927388
DOI: 10.1038/s41594-021-00585-7

実験手法

ELECTRON MICROSCOPY (3.4 Å)