7LTX

EGFR (T790M/V948R) in complex with quinazolinone allosteric inhibitor

Summary for 7LTX

Entry DOI	10.2210/pdb7ltx/pdb
Descriptor	Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	egfr, kinase, allosteric, inhibitor, quinazolinone, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	155235.00
Authors	Beyett, T.S.,Eck, M.J. (deposition date: 2021-02-20, release date: 2022-02-23, Last modification date: 2023-10-18)
Primary citation	Gero, T.W.,Heppner, D.E.,Beyett, T.S.,To, C.,Azevedo, S.C.,Jang, J.,Bunnell, T.,Feru, F.,Li, Z.,Shin, B.H.,Soroko, K.M.,Gokhale, P.C.,Gray, N.S.,Janne, P.A.,Eck, M.J.,Scott, D.A. Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. Bioorg.Med.Chem.Lett., 68:128718-128718, 2022 Cited by PubMed: 35378251 DOI: 10.1016/j.bmcl.2022.128718 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation