7LTN

Crystal structure of Mpro in complex with inhibitor CDD-1713

7LTN の概要

• エントリーDOI: 10.2210/pdb7ltn/pdb
• 分子名称: 3C-like proteinase, 2-[4-(1~{H}-indazol-4-yl)-2-methanoyl-6-methoxy-phenoxy]-~{N},~{N}-dimethyl-ethanamide (3 entities in total)
• 機能のキーワード: sars-cov-2 main protease, nanomolar potency inhibitor, dna-encoded library, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV,SARS-CoV-2)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34178.92

構造登録者

Lu, S.,Palzkill, T.,Matzuk, M.,Young, D.,Melek, N.,Chamakuri, S. (登録日: 2021-02-19, 公開日: 2021-11-10, 最終更新日: 2023-10-18)

• 主引用文献: Chamakuri, S.,Lu, S.,Ucisik, M.N.,Bohren, K.M.,Chen, Y.C.,Du, H.C.,Faver, J.C.,Jimmidi, R.,Li, F.,Li, J.Y.,Nyshadham, P.,Palmer, S.S.,Pollet, J.,Qin, X.,Ronca, S.E.,Sankaran, B.,Sharma, K.L.,Tan, Z.,Versteeg, L.,Yu, Z.,Matzuk, M.M.,Palzkill, T.,Young, D.W.; DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M pro inhibitors.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34426525; DOI: 10.1073/pnas.2111172118

実験手法

X-RAY DIFFRACTION (1.79 Å)