7LSG

Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV EDIII (Siberian Subtype)

Summary for 7LSG

Entry DOI	10.2210/pdb7lsg/pdb
Descriptor	T025 Fab Heavy Chain, T025 Fab Light Chain, Core protein, ... (4 entities in total)
Functional Keywords	tick-borne encephalitis virus, antibody, ediii, tbev, immune system, immune system-viral protein complex, immune system/viral protein
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	58937.87
Authors	Keeffe, J.R.,Bjorkman, P.J. (deposition date: 2021-02-18, release date: 2021-04-07, Last modification date: 2023-10-18)
Primary citation	Agudelo, M.,Palus, M.,Keeffe, J.R.,Bianchini, F.,Svoboda, P.,Salat, J.,Peace, A.,Gazumyan, A.,Cipolla, M.,Kapoor, T.,Guidetti, F.,Yao, K.H.,Elsterova, J.,Teislerova, D.,Chrdle, A.,Honig, V.,Oliveira, T.,West, A.P.,Lee, Y.E.,Rice, C.M.,MacDonald, M.R.,Bjorkman, P.J.,Ruzek, D.,Robbiani, D.F.,Nussenzweig, M.C. Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease. J.Exp.Med., 218:-, 2021 Cited by PubMed: 33831141 DOI: 10.1084/jem.20210236 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation