7LSG

Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV EDIII (Siberian Subtype)

7LSG の概要

• エントリーDOI: 10.2210/pdb7lsg/pdb
• 分子名称: T025 Fab Heavy Chain, T025 Fab Light Chain, Core protein, ... (4 entities in total)
• 機能のキーワード: tick-borne encephalitis virus, antibody, ediii, tbev, immune system, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 58937.87

構造登録者

Keeffe, J.R.,Bjorkman, P.J. (登録日: 2021-02-18, 公開日: 2021-04-07, 最終更新日: 2023-10-18)

• 主引用文献: Agudelo, M.,Palus, M.,Keeffe, J.R.,Bianchini, F.,Svoboda, P.,Salat, J.,Peace, A.,Gazumyan, A.,Cipolla, M.,Kapoor, T.,Guidetti, F.,Yao, K.H.,Elsterova, J.,Teislerova, D.,Chrdle, A.,Honig, V.,Oliveira, T.,West, A.P.,Lee, Y.E.,Rice, C.M.,MacDonald, M.R.,Bjorkman, P.J.,Ruzek, D.,Robbiani, D.F.,Nussenzweig, M.C.; Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease.; J.Exp.Med., 218:-, 2021; PubMed: 33831141; DOI: 10.1084/jem.20210236

実験手法

X-RAY DIFFRACTION (1.86 Å)