7LQU

Crystal Structure of HIV-1 RT in Complex with NBD-14075

7LQU の概要

• エントリーDOI: 10.2210/pdb7lqu/pdb
• 分子名称: Reverse transcriptase p66, Reverse transcriptase p51, ~{N}-[(1~{R})-2-azanyl-1-[5-(hydroxymethyl)-1,3-thiazol-2-yl]ethyl]-5-(4-chloranyl-3-fluoranyl-phenyl)-1~{H}-pyrrole-2-carboxamide, ... (5 entities in total)
• 機能のキーワード: human immunodeficiency virus 1, non nucleotide-reverse transcriptase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114768.82

構造登録者

Losada, N.,Ruiz, F.X.,Gruber, K.,Das, K.,Arnold, E. (登録日: 2021-02-15, 公開日: 2021-11-17, 最終更新日: 2023-10-18)

• 主引用文献: Losada, N.,Ruiz, F.X.,Curreli, F.,Gruber, K.,Pilch, A.,Das, K.,Debnath, A.K.,Arnold, E.; HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites.; J.Med.Chem., 64:16530-16540, 2021; PubMed: 34735153; DOI: 10.1021/acs.jmedchem.1c01104

実験手法

X-RAY DIFFRACTION (2.6 Å)