7LPK

Crystal structure of BPTF bromodomain in complex with inhibitor HZ-03-112

Summary for 7LPK

Entry DOI	10.2210/pdb7lpk/pdb
Related	7LP0
Descriptor	Nucleosome-remodeling factor subunit BPTF, 4-chloranyl-2-methyl-5-[[(3~{R})-pyrrolidin-3-yl]amino]pyridazin-3-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	bptf, bromodomain, inhibitor, gene regulation, gene regulation-inhibitor complex, gene regulation/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	30050.94
Authors	Chan, A.,Schonbrunn, E. (deposition date: 2021-02-12, release date: 2022-08-10, Last modification date: 2024-02-21)
Primary citation	Zahid, H.,Buchholz, C.R.,Singh, M.,Ciccone, M.F.,Chan, A.,Nithianantham, S.,Shi, K.,Aihara, H.,Fischer, M.,Schonbrunn, E.,Dos Santos, C.O.,Landry, J.W.,Pomerantz, W.C.K. New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64:13902-13917, 2021 Cited by PubMed: 34515477 DOI: 10.1021/acs.jmedchem.1c01294 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.39 Å)

Structure validation