7LPK

Crystal structure of BPTF bromodomain in complex with inhibitor HZ-03-112

7LPK の概要

• エントリーDOI: 10.2210/pdb7lpk/pdb
• 関連するPDBエントリー: 7LP0
• 分子名称: Nucleosome-remodeling factor subunit BPTF, 4-chloranyl-2-methyl-5-[[(3~{R})-pyrrolidin-3-yl]amino]pyridazin-3-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bptf, bromodomain, inhibitor, gene regulation, gene regulation-inhibitor complex, gene regulation/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30050.94

構造登録者

Chan, A.,Schonbrunn, E. (登録日: 2021-02-12, 公開日: 2022-08-10, 最終更新日: 2024-02-21)

• 主引用文献: Zahid, H.,Buchholz, C.R.,Singh, M.,Ciccone, M.F.,Chan, A.,Nithianantham, S.,Shi, K.,Aihara, H.,Fischer, M.,Schonbrunn, E.,Dos Santos, C.O.,Landry, J.W.,Pomerantz, W.C.K.; New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition.; J.Med.Chem., 64:13902-13917, 2021; PubMed: 34515477; DOI: 10.1021/acs.jmedchem.1c01294

実験手法

X-RAY DIFFRACTION (1.39 Å)