7LOM

Ornithine Aminotransferase (OAT) soaked with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid

7LOM の概要

• エントリーDOI: 10.2210/pdb7lom/pdb
• 分子名称: Ornithine aminotransferase, mitochondrial, THREONINE, (3~{S},4~{S})-4-methyl-3-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclohexene-1-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: ornithine aminotransferase, oat, aminotransferase, inactivator, inhibitor, transferase, transferase-inactivator complex, transferase/inactivator
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 136115.32

構造登録者

Butrin, A.,Zhu, W.,Liu, D.,Silverman, R. (登録日: 2021-02-10, 公開日: 2021-08-25, 最終更新日: 2023-10-18)

• 主引用文献: Zhu, W.,Doubleday, P.F.,Butrin, A.,Weerawarna, P.M.,Melani, R.D.,Catlin, D.S.,Dwight, T.A.,Liu, D.,Kelleher, N.L.,Silverman, R.B.; Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.; J.Am.Chem.Soc., 143:8193-8207, 2021; PubMed: 34014654; DOI: 10.1021/jacs.1c03572

実験手法

X-RAY DIFFRACTION (2.1 Å)