7LNQ

Structure of the avibactam-CDD-1 3 minute complex in imidazole and MPD

7LNQ の概要

• エントリーDOI: 10.2210/pdb7lnq/pdb
• 分子名称: Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, CARBON DIOXIDE, ... (6 entities in total)
• 機能のキーワード: beta-lactamase, antibiotic resistance, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Clostridioides difficile
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36856.75

構造登録者

Smith, C.A.,Vakulenko, S.B.,Stewart, N.K. (登録日: 2021-02-08, 公開日: 2021-05-12, 最終更新日: 2023-11-15)

• 主引用文献: Stewart, N.K.,Toth, M.,Stasyuk, A.,Vakulenko, S.B.,Smith, C.A.; In Crystallo Time-Resolved Interaction of the Clostridioides difficile CDD-1 enzyme with Avibactam Provides New Insights into the Catalytic Mechanism of Class D beta-lactamases.; Acs Infect Dis., 7:1765-1776, 2021; PubMed: 33908775; DOI: 10.1021/acsinfecdis.1c00094

実験手法

X-RAY DIFFRACTION (1.73 Å)