7LMX

A HIGHLY SPECIFIC INHIBITOR OF INTEGRIN ALPHA-V BETA-6 WITH A DISULFIDE

7LMX の概要

• エントリーDOI: 10.2210/pdb7lmx/pdb
• 分子名称: Integrin inhibitor (2 entities in total)
• 機能のキーワード: de novo design, inhibitor, integrin, fibrosis, de novo protein
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 25640.54

構造登録者

Dong, X.,Bera, A.K.,Roy, A.,Shi, L.,Springer, T.A.,Baker, D. (登録日: 2021-02-06, 公開日: 2022-08-10, 最終更新日: 2024-04-03)

• 主引用文献: Roy, A.,Shi, L.,Chang, A.,Dong, X.,Fernandez, A.,Kraft, J.C.,Li, J.,Le, V.Q.,Winegar, R.V.,Cherf, G.M.,Slocum, D.,Poulson, P.D.,Casper, G.E.,Vallecillo-Zuniga, M.L.,Valdoz, J.C.,Miranda, M.C.,Bai, H.,Kipnis, Y.,Olshefsky, A.,Priya, T.,Carter, L.,Ravichandran, R.,Chow, C.M.,Johnson, M.R.,Cheng, S.,Smith, M.,Overed-Sayer, C.,Finch, D.K.,Lowe, D.,Bera, A.K.,Matute-Bello, G.,Birkland, T.P.,DiMaio, F.,Raghu, G.,Cochran, J.R.,Stewart, L.J.,Campbell, M.G.,Van Ry, P.M.,Springer, T.,Baker, D.; De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8.; Nat Commun, 14:5660-5660, 2023; PubMed: 37704610; DOI: 10.1038/s41467-023-41272-z

実験手法

X-RAY DIFFRACTION (1.8 Å)