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7LMP

Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 36 [3-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-8-(1H-imidazole-4-carbonyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione]

7LMP の概要
エントリーDOI10.2210/pdb7lmp/pdb
分子名称JTO light chain, PHOSPHATE ION, 3-[2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl]-8-(1~{H}-imidazol-5-ylcarbonyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione, ... (4 entities in total)
機能のキーワードamyloidosis, immune system
由来する生物種Homo sapiens (Human)
タンパク質・核酸の鎖数2
化学式量合計47133.61
構造登録者
Yan, N.L.,Wilson, I.A.,Kelly, J.W. (登録日: 2021-02-05, 公開日: 2021-05-19, 最終更新日: 2023-10-18)
主引用文献Yan, N.L.,Santos-Martins, D.,Nair, R.,Chu, A.,Wilson, I.A.,Johnson, K.A.,Forli, S.,Morgan, G.J.,Petrassi, H.M.,Kelly, J.W.
Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
J.Med.Chem., 64:6273-6299, 2021
Cited by
PubMed: 33939422
DOI: 10.1021/acs.jmedchem.1c00339
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.29 Å)
構造検証レポート
Validation report summary of 7lmp
検証レポート(詳細版)ダウンロードをダウンロード

221051

件を2024-06-12に公開中

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