7LLY

Oxyntomodulin-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein

7LLY の概要

• エントリーDOI: 10.2210/pdb7lly/pdb
• EMDBエントリー: 23436
• 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: glucagon-like peptide-1 (glp-1) receptor, oxyntomodulin, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 164535.36

構造登録者

Wootten, D.,Sexton, P.M.,Belousoff, M.J.,Danev, R.,Zhang, X.,Khoshouei, M.,Venugopal, H. (登録日: 2021-02-04, 公開日: 2022-01-12, 最終更新日: 2022-01-26)

• 主引用文献: Deganutti, G.,Liang, Y.L.,Zhang, X.,Khoshouei, M.,Clydesdale, L.,Belousoff, M.J.,Venugopal, H.,Truong, T.T.,Glukhova, A.,Keller, A.N.,Gregory, K.J.,Leach, K.,Christopoulos, A.,Danev, R.,Reynolds, C.A.,Zhao, P.,Sexton, P.M.,Wootten, D.; Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.; Nat Commun, 13:92-92, 2022; PubMed: 35013280; DOI: 10.1038/s41467-021-27760-0

実験手法

ELECTRON MICROSCOPY (3.3 Å)