7LL9
D-Protein RFX-V2 Bound to the VEGFR1 Domain 3 Site on VEGF-A
Summary for 7LL9
Entry DOI | 10.2210/pdb7ll9/pdb |
Descriptor | Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V2 (2 entities in total) |
Functional Keywords | d-protein, antagonist, biosynthetic protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 75168.91 |
Authors | Marinec, P.S.,Landgraf, K.E.,Uppalapati, M.,Chen, G.,Xie, D.,Jiang, Q.,Zhao, Y.,Petriello, A.,Deshayes, K.,Kent, S.B.H.,Ault-Riche, D.,Sidhu, S.S. (deposition date: 2021-02-03, release date: 2021-03-03, Last modification date: 2023-11-15) |
Primary citation | Marinec, P.S.,Landgraf, K.E.,Uppalapati, M.,Chen, G.,Xie, D.,Jiang, Q.,Zhao, Y.,Petriello, A.,Deshayes, K.,Kent, S.B.H.,Ault-Riche, D.,Sidhu, S.S. A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth. Acs Chem.Biol., 16:548-556, 2021 Cited by PubMed: 33621466DOI: 10.1021/acschembio.1c00017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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