7LK1

Ornithine Aminotransferase (OAT) with its potent inhibitor - (S)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (SS-1-148) - 1 Hour Soaking

7LK1 の概要

• エントリーDOI: 10.2210/pdb7lk1/pdb
• 分子名称: Ornithine aminotransferase, mitochondrial, (1R,4R)-4-fluoro-3-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopent-2-ene-1-carboxylic acid (3 entities in total)
• 機能のキーワード: ornithine aminotransferase, oat, aminotransferase, inhibitor, inactivator, ss-1-148, soaking, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 135709.78

構造登録者

Butrin, A.,Shen, S.,Liu, D.,Silverman, R. (登録日: 2021-02-01, 公開日: 2022-02-16, 最終更新日: 2024-03-13)

• 主引用文献: Shen, S.,Butrin, A.,Doubleday, P.F.,Melani, R.D.,Beaupre, B.A.,Tavares, M.T.,Ferreira, G.M.,Kelleher, N.L.,Moran, G.R.,Liu, D.,Silverman, R.B.; Turnover and Inactivation Mechanisms for ( S )-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase.; J.Am.Chem.Soc., 143:8689-8703, 2021; PubMed: 34097381; DOI: 10.1021/jacs.1c02456

実験手法

X-RAY DIFFRACTION (1.79 Å)