7LHP

Crystal Structure of EcDsbA in a complex with methyl 2-(6-bromo-2-phenylbenzofuran-3-yl)acetate

7LHP の概要

• エントリーDOI: 10.2210/pdb7lhp/pdb
• 分子名称: Thiol:disulfide interchange protein DsbA, (6-bromo-2-phenyl-1-benzofuran-3-yl)acetic acid, COPPER (II) ION, ... (4 entities in total)
• 機能のキーワード: disulfide oxidoreductase, redox protein, oxidoreductase-inhibitor complex, oxidoreductase, oxidoreductase/inhibitor
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42704.76

構造登録者

Ilyichova, O.V.,Scanlon, M.J. (登録日: 2021-01-26, 公開日: 2021-08-11, 最終更新日: 2023-10-18)

• 主引用文献: Duncan, L.F.,Wang, G.,Ilyichova, O.V.,Dhouib, R.,Totsika, M.,Scanlon, M.J.,Heras, B.,Abbott, B.M.; Elaboration of a benzofuran scaffold and evaluation of binding affinity and inhibition of Escherichia coli DsbA: A fragment-based drug design approach to novel antivirulence compounds.; Bioorg.Med.Chem., 45:116315-116315, 2021; PubMed: 34364222; DOI: 10.1016/j.bmc.2021.116315

実験手法

X-RAY DIFFRACTION (1.9 Å)