7LGI

The haddock model of GDP KRas in complex with promazine using chemical shift perturbations and intermolecular NOEs

Summary for 7LGI

• Entry DOI: 10.2210/pdb7lgi/pdb
• Related: 6V5L
• NMR Information: BMRB: 30845
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: gdp kras, small molecule ligand, haddock structure model, chemical shift changes, intermolecular noe, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 20023.69

Authors

Wang, X.,Gorfe, A.A.,Putkey, J.A. (deposition date: 2021-01-20, release date: 2021-07-21, Last modification date: 2024-05-01)

• Primary citation: Wang, X.,Gorfe, A.A.,Putkey, J.A.; Antipsychotic phenothiazine drugs bind to KRAS in vitro.; J.Biomol.Nmr, 75:233-244, 2021; PubMed: 34176062; DOI: 10.1007/s10858-021-00371-z

Experimental method

SOLUTION NMR