7LG8
EGFR (T79M/V948R) in complex with naquotinib and an allosteric inhibitor
Summary for 7LG8
Entry DOI | 10.2210/pdb7lg8/pdb |
Descriptor | Epidermal growth factor receptor, (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, 6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazin e-2-carboxamide, ... (4 entities in total) |
Functional Keywords | egfr, kinase, inhibitor, allosteric, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 155375.82 |
Authors | Beyett, T.S.,Eck, M.J. (deposition date: 2021-01-19, release date: 2022-02-23, Last modification date: 2023-10-18) |
Primary citation | Beyett, T.S.,To, C.,Heppner, D.E.,Rana, J.K.,Schmoker, A.M.,Jang, J.,De Clercq, D.J.H.,Gomez, G.,Scott, D.A.,Gray, N.S.,Janne, P.A.,Eck, M.J. Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nat Commun, 13:2530-2530, 2022 Cited by PubMed: 35534503DOI: 10.1038/s41467-022-30258-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.93 Å) |
Structure validation
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