7LEZ

Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:2 mAb1 complex

7LEZ の概要

• エントリーDOI: 10.2210/pdb7lez/pdb
• EMDBエントリー: 23295
• 分子名称: mAb1 heavy chain, mAb1 light chain, Arginase-1, ... (4 entities in total)
• 機能のキーワード: arginase, metalloenzyme, immune system, hydrolase-immune system complex, hydrolase/immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 14
• 化学式量合計: 504372.81

構造登録者

Gomez-Llorente, Y.,Scapin, G.,Palte, R.L. (登録日: 2021-01-15, 公開日: 2021-09-01)

• 主引用文献: Palte, R.L.,Juan, V.,Gomez-Llorente, Y.,Bailly, M.A.,Chakravarthy, K.,Chen, X.,Cipriano, D.,Fayadat-Dilman, L.,Gathiaka, S.,Greb, H.,Hall, B.,Handa, M.,Hsieh, M.,Kofman, E.,Lin, H.,Miller, J.R.,Nguyen, N.,O'Neil, J.,Shaheen, H.,Sterner, E.,Strickland, C.,Sun, A.,Taremi, S.,Scapin, G.; Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.; Commun Biol, 4:927-927, 2021; PubMed: 34326456; DOI: 10.1038/s42003-021-02444-z

実験手法

ELECTRON MICROSCOPY (4.15 Å)