7LEO

C1B domain of Protein kinase C in complex with diacylglycerol-lactone (AJH-836) and 1,2-diheptanoyl-sn-glycero-3-phosphocholine

7LEO の概要

• エントリーDOI: 10.2210/pdb7leo/pdb
• 分子名称: Protein kinase C delta type, ZINC ION, (4S,7R)-7-(heptanoyloxy)-4-hydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphahexadecan-1-aminium 4-oxide, ... (5 entities in total)
• 機能のキーワード: c1, lipid-binding, diacylglycerol-binding, zn2+ finger, lipid binding protein
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 14286.31

構造登録者

Katti, S.S.,Krieger, I. (登録日: 2021-01-14, 公開日: 2022-05-04, 最終更新日: 2023-10-18)

• 主引用文献: Katti, S.S.,Krieger, I.V.,Ann, J.,Lee, J.,Sacchettini, J.C.,Igumenova, T.I.; Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists.; Nat Commun, 13:2695-2695, 2022; PubMed: 35577811; DOI: 10.1038/s41467-022-30389-2

実験手法

X-RAY DIFFRACTION (1.65 Å)