7LE1
HIV-1 Protease WT (NL4-3) in Complex with UMass2
7LE1 の概要
エントリーDOI | 10.2210/pdb7le1/pdb |
分子名称 | Protease, SULFATE ION, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}propyl]carbamate, ... (4 entities in total) |
機能のキーワード | hiv, nl4-3 protease, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Human immunodeficiency virus 1 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 22432.49 |
構造登録者 | Lockbaum, G.J.,Rusere, L.N.,Henes, M.,Kosovrasti, K.,Lee, S.K.,Spielvogel, E.,Nalivaika, E.A.,Swanstrom, R.,KurtYilmaz, N.,Schiffer, C.A.,Ali, A. (登録日: 2021-01-14, 公開日: 2022-07-06, 最終更新日: 2023-10-18) |
主引用文献 | Lockbaum, G.J.,Rusere, L.N.,Henes, M.,Kosovrasti, K.,Lee, S.K.,Spielvogel, E.,Nalivaika, E.A.,Swanstrom, R.,KurtYilmaz, N.,Schiffer, C.A.,Ali, A. HIV-1 Protease Inhibitors with a P1 Phosphonate Modification Maintain Potency against Drug Resistant Variants by Increased van der Waals Contacts with Flaps Residues To Be Published, |
実験手法 | X-RAY DIFFRACTION (2.001 Å) |
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