7LCZ

Crystal structure of the ARM domain from Drosophila SARM1 in complex with NMN

Summary for 7LCZ

Entry DOI	10.2210/pdb7lcz/pdb
Descriptor	Isoform B of NAD(+) hydrolase sarm1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	nadase, autoinhibition, arm domain, allostery, signaling protein, hydrolase
Biological source	Drosophila melanogaster (Fruit fly)
Total number of polymer chains	2
Total formula weight	69389.94
Authors	Gu, W.,Nanson, J.D.,Luo, Z.,Jia, X.,Manik, M.K.,Ve, T.,Kobe, B. (deposition date: 2021-01-12, release date: 2021-03-10, Last modification date: 2024-03-06)
Primary citation	Figley, M.D.,Gu, W.,Nanson, J.D.,Shi, Y.,Sasaki, Y.,Cunnea, K.,Malde, A.K.,Jia, X.,Luo, Z.,Saikot, F.K.,Mosaiab, T.,Masic, V.,Holt, S.,Hartley-Tassell, L.,McGuinness, H.Y.,Manik, M.K.,Bosanac, T.,Landsberg, M.J.,Kerry, P.S.,Mobli, M.,Hughes, R.O.,Milbrandt, J.,Kobe, B.,DiAntonio, A.,Ve, T. SARM1 is a metabolic sensor activated by an increased NMN/NAD + ratio to trigger axon degeneration. Neuron, 109:1118-, 2021 Cited by PubMed: 33657413 DOI: 10.1016/j.neuron.2021.02.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation