7LBR

SARS-CoV-2 papain-like protease (PLpro) bound to inhibitor XR8-89

7LBR の概要

• エントリーDOI: 10.2210/pdb7lbr/pdb
• 分子名称: Non-structural protein 3, ZINC ION, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: papain-like protease, coronavirus inhibitor, sars-cov-2, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73225.79

構造登録者

Ratia, K.M.,Xiong, R.,Thatcher, G.R. (登録日: 2021-01-08, 公開日: 2021-02-24, 最終更新日: 2023-10-18)

• 主引用文献: Shen, Z.,Ratia, K.,Cooper, L.,Kong, D.,Lee, H.,Kwon, Y.,Li, Y.,Alqarni, S.,Huang, F.,Dubrovskyi, O.,Rong, L.,Thatcher, G.R.,Xiong, R.; Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures.; Biorxiv, 2021; PubMed: 33594371; DOI: 10.1101/2021.02.13.431008

実験手法

X-RAY DIFFRACTION (2.2 Å)