7L9L

Crystal structure of the second bromodomain (BD2) of human BRD3 bound to BI2536

7L9L の概要

• エントリーDOI: 10.2210/pdb7l9l/pdb
• 分子名称: Bromodomain-containing protein 3, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bet, erk5, dual brd-kinase inhibitor, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13891.12

構造登録者

Karim, M.R.,Bikowitz, M.J.,Schonbrunn, E. (登録日: 2021-01-04, 公開日: 2021-07-07, 最終更新日: 2023-10-18)

• 主引用文献: Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E.; Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.; J.Med.Chem., 64:15772-15786, 2021; PubMed: 34710325; DOI: 10.1021/acs.jmedchem.1c01096

実験手法

X-RAY DIFFRACTION (1.55 Å)