7L8L
Crystal structure of human R152H GPX4-U46C
Summary for 7L8L
Entry DOI | 10.2210/pdb7l8l/pdb |
Descriptor | Phospholipid hydroperoxide glutathione peroxidase, THIOCYANATE ION (3 entities in total) |
Functional Keywords | alpha-beta protein, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 21927.13 |
Authors | Forouhar, F.,Liu, H.,Seibt, T.,Saneto, R.,Wigby, K.,Friedman, J.,Xia, X.,Shchepinov, M.S.,Ramesh, S.,Conrad, M.,Stockwell, B.R. (deposition date: 2020-12-31, release date: 2021-12-29, Last modification date: 2023-10-18) |
Primary citation | Liu, H.,Forouhar, F.,Seibt, T.,Saneto, R.,Wigby, K.,Friedman, J.,Xia, X.,Shchepinov, M.S.,Ramesh, S.,Conrad, M.,Stockwell, B.R. Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism Nat.Chem.Biol., 2021 |
Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
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