7L34

Human DNA Ligase 1 - R641L nicked DNA complex

Summary for 7L34

• Entry DOI: 10.2210/pdb7l34/pdb
• Descriptor: DNA ligase 1, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*GP*AP*C)-3'), ... (6 entities in total)
• Functional Keywords: dna ligase, ligase, ligase-dna complex, ligase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 83321.60

Authors

Tumbale, P.P.,Williams, R.S.,Schellenberg, M.S. (deposition date: 2020-12-17, release date: 2021-01-13, Last modification date: 2023-10-18)

• Primary citation: Jurkiw, T.J.,Tumbale, P.P.,Schellenberg, M.J.,Cunningham-Rundles, C.,Williams, R.S.,O'Brien, P.J.; LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency.; Nucleic Acids Res., 49:1619-1630, 2021; PubMed: 33444456; DOI: 10.1093/nar/gkaa1297

Experimental method

X-RAY DIFFRACTION (1.901 Å)