7L2X

cryo-EM structure of RTX-bound minimal TRPV1 with NMDG at state c

Summary for 7L2X

• Entry DOI: 10.2210/pdb7l2x/pdb
• EMDB information: 23144
• Descriptor: Transient receptor potential cation channel subfamily V member 1, resiniferatoxin, (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate, ... (4 entities in total)
• Functional Keywords: trp channel, cryo-em, nanodisc, large cation, vanilloid agonist, transport protein
• Biological source: Rattus norvegicus (Rat)
• Total number of polymer chains: 4
• Total formula weight: 297038.33

Authors

Zhang, K.,Julius, D.,Cheng, Y. (deposition date: 2020-12-17, release date: 2021-09-22, Last modification date: 2024-05-29)

• Primary citation: Zhang, K.,Julius, D.,Cheng, Y.; Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.; Cell, 184:5138-, 2021; PubMed: 34496225; DOI: 10.1016/j.cell.2021.08.012

Experimental method

ELECTRON MICROSCOPY (3.26 Å)