7L2U

cryo-EM structure of DkTx-bound minimal TRPV1 in open state

Summary for 7L2U

• Entry DOI: 10.2210/pdb7l2u/pdb
• EMDB information: 23141
• Descriptor: Transient receptor potential cation channel subfamily V member 1, Tau-theraphotoxin-Hs1a, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, ... (6 entities in total)
• Functional Keywords: trp channel, cryo-em, nanodisc, toxin, transport protein
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 6
• Total formula weight: 313864.64

Authors

Zhang, K.,Julius, D.,Cheng, Y. (deposition date: 2020-12-17, release date: 2021-09-22, Last modification date: 2021-10-13)

• Primary citation: Zhang, K.,Julius, D.,Cheng, Y.; Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.; Cell, 184:5138-5150.e12, 2021; PubMed: 34496225; DOI: 10.1016/j.cell.2021.08.012

Experimental method

ELECTRON MICROSCOPY (3.47 Å)